Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice
Identifieur interne : 004429 ( Main/Exploration ); précédent : 004428; suivant : 004430Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice
Auteurs : Nadine De Albuquerque [Canada] ; Ehtesham Baig [Canada] ; XUEZHONG MA [Canada] ; JIANHUA ZHANG [Canada] ; William He [Canada] ; Andrea Rowe [Canada] ; Marlena Habal [Canada] ; MINGFENG LIU [Canada] ; Itay Shalev [Canada] ; Gregory P. Downey [Canada] ; Reginald Gorczynski [Canada] ; Jagdish Butany [Canada] ; Julian Leibowitz [États-Unis] ; Susan R. Weiss [États-Unis] ; Ian D. Mcgilvray [Canada] ; M. James Phillips [Canada] ; Eleanor N. Fish [Canada] ; Gary A. Levy [Canada]Source :
- Journal of virology [ 0022-538X ] ; 2006.
Descripteurs français
- KwdFr :
- ADN complémentaire (génétique), ARN messager (génétique), ARN messager (métabolisme), Animaux, Cytokines (génétique), Cytokines (métabolisme), Femelle, Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (génétique), Infections à coronavirus (immunologie), Infections à coronavirus (étiologie), Interférons (génétique), Interférons (métabolisme), Microscopie électronique, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Souris, Souris de lignée A, Souris de lignée BALB C, Souris de lignée C3H, Souris de lignée C57BL, Spécificité d'espèce, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (étiologie), Séquence nucléotidique, Virus de l'hépatite murine (), Virus de l'hépatite murine (immunologie), Virus de l'hépatite murine (pathogénicité).
- MESH :
- anatomopathologie : Infections à coronavirus, Poumon, Syndrome respiratoire aigu sévère.
- génétique : ADN complémentaire, ARN messager, Cytokines, Infections à coronavirus, Interférons, Syndrome respiratoire aigu sévère.
- immunologie : Infections à coronavirus, Syndrome respiratoire aigu sévère, Virus de l'hépatite murine.
- métabolisme : ARN messager, Cytokines, Interférons.
- pathogénicité : Virus de l'hépatite murine.
- virologie : Poumon.
- étiologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Animaux, Femelle, Humains, Microscopie électronique, Modèles animaux de maladie humaine, Souris, Souris de lignée A, Souris de lignée BALB C, Souris de lignée C3H, Souris de lignée C57BL, Spécificité d'espèce, Séquence nucléotidique, Virus de l'hépatite murine, Virus hépatite murine, Virus hépatite A, Souris, Souche, Modèle, Microbiologie, Virologie, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, Base Sequence, Coronavirus Infections (etiology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (pathology), Cytokines (genetics), Cytokines (metabolism), DNA, Complementary (genetics), Disease Models, Animal, Female, Hepatitis A virus, Humans, Interferons (genetics), Interferons (metabolism), Lung (pathology), Lung (virology), Mice, Mice, Inbred A, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Microbiology, Microscopy, Electron, Models, Mouse, Murine hepatitis virus, Murine hepatitis virus (classification), Murine hepatitis virus (immunology), Murine hepatitis virus (pathogenicity), RNA, Messenger (genetics), RNA, Messenger (metabolism), Severe Acute Respiratory Syndrome (etiology), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology), Severe acute respiratory syndrome, Species Specificity, Strain, Virology.
- MESH :
- chemical , genetics : Cytokines, DNA, Complementary, Interferons, RNA, Messenger.
- classification : Murine hepatitis virus.
- etiology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- genetics : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- immunology : Coronavirus Infections, Murine hepatitis virus, Severe Acute Respiratory Syndrome.
- chemical , metabolism : Cytokines, Interferons, RNA, Messenger.
- pathogenicity : Murine hepatitis virus.
- pathology : Coronavirus Infections, Lung, Severe Acute Respiratory Syndrome.
- virology : Lung.
- Animals, Base Sequence, Disease Models, Animal, Female, Humans, Mice, Mice, Inbred A, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Microscopy, Electron, Species Specificity.
Abstract
Severe acute respiratory syndrome (SARS) is a life-threatening infectious disease which has been difficult to study and treat because of the lack of a readily available animal model. Intranasal infection of A/J mice with the coronavirus murine hepatitis virus strain 1 (MHV-1) produced pulmonary pathological features of SARS. All MHV-1-infected A/J mice developed progressive interstitial pneumonitis, including dense macrophage infiltrates, giant cells, and hyaline membranes, resulting in death of all animals. In contrast, other mouse strains developed only mild transitory disease. Infected A/J mice had significantly higher cytokine levels, particularly macrophage chemoattractant protein 1 (MCP-1/CCL-2), gamma interferon, and tumor necrosis factor alpha. Furthermore, FGL2/fibroleukin mRNA transcripts and protein and fibrin deposits were markedly increased in the lungs of infected A/J mice. These animals developed a less robust type I interferon response to MHV-1 infection than resistant C57BL/6J mice, and treatment with recombinant beta interferon improved survival. This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies.
Affiliations:
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sort="Downey, Gregory P" uniqKey="Downey G" first="Gregory P." last="Downey">Gregory P. Downey</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Gorczynski, Reginald" sort="Gorczynski, Reginald" uniqKey="Gorczynski R" first="Reginald" last="Gorczynski">Reginald Gorczynski</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Surgery, University Health Network</s1><s3>CAN</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Surgery, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Butany, Jagdish" sort="Butany, Jagdish" uniqKey="Butany J" first="Jagdish" last="Butany">Jagdish Butany</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Pathology, University Health Network</s1><s3>CAN</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pathology, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Leibowitz, Julian" sort="Leibowitz, Julian" uniqKey="Leibowitz J" first="Julian" last="Leibowitz">Julian Leibowitz</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Microbial and Molecular Pathogenesis, Texas A&M University System- HSC</s1><s2>College Station, Texas</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Microbiology, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Surgery, University Health Network</s1><s3>CAN</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Surgery, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, M James" sort="Phillips, M James" uniqKey="Phillips M" first="M. James" last="Phillips">M. James Phillips</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Pathology, University Health Network</s1><s3>CAN</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pathology, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N." last="Fish">Eleanor N. Fish</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0518531</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0518531 INIST</idno><idno type="RBID">Pascal:06-0518531</idno><idno type="wicri:Area/PascalFrancis/Corpus">000437</idno><idno type="wicri:Area/PascalFrancis/Curation">000553</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000450</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000450</idno><idno type="wicri:doubleKey">0022-538X:2006:De Albuquerque N:murine:hepatitis:virus</idno><idno type="wicri:Area/Main/Merge">004651</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:17041219</idno><idno type="wicri:Area/PubMed/Corpus">002017</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002017</idno><idno type="wicri:Area/PubMed/Curation">002017</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002017</idno><idno type="wicri:Area/PubMed/Checkpoint">002096</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002096</idno><idno type="wicri:Area/Ncbi/Merge">001734</idno><idno type="wicri:Area/Ncbi/Curation">001734</idno><idno type="wicri:Area/Ncbi/Checkpoint">001734</idno><idno type="wicri:doubleKey">0022-538X:2006:De Albuquerque N:murine:hepatitis:virus</idno><idno type="wicri:Area/Main/Merge">003F87</idno><idno type="wicri:Area/Main/Curation">004429</idno><idno type="wicri:Area/Main/Exploration">004429</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice</title><author><name sortKey="De Albuquerque, Nadine" sort="De Albuquerque, Nadine" uniqKey="De Albuquerque N" first="Nadine" last="De Albuquerque">Nadine De Albuquerque</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Baig, Ehtesham" sort="Baig, Ehtesham" uniqKey="Baig E" first="Ehtesham" last="Baig">Ehtesham Baig</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Xuezhong Ma" sort="Xuezhong Ma" uniqKey="Xuezhong Ma" last="Xuezhong Ma">XUEZHONG MA</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Jianhua Zhang" sort="Jianhua Zhang" uniqKey="Jianhua Zhang" last="Jianhua Zhang">JIANHUA ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="He, William" sort="He, William" uniqKey="He W" first="William" last="He">William He</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, Andrea" sort="Rowe, Andrea" uniqKey="Rowe A" first="Andrea" last="Rowe">Andrea Rowe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Habal, Marlena" sort="Habal, Marlena" uniqKey="Habal M" first="Marlena" last="Habal">Marlena Habal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Mingfeng Liu" sort="Mingfeng Liu" uniqKey="Mingfeng Liu" last="Mingfeng Liu">MINGFENG LIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Shalev, Itay" sort="Shalev, Itay" uniqKey="Shalev I" first="Itay" last="Shalev">Itay Shalev</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Downey, Gregory P" sort="Downey, Gregory P" uniqKey="Downey G" first="Gregory P." last="Downey">Gregory P. Downey</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Gorczynski, Reginald" sort="Gorczynski, Reginald" uniqKey="Gorczynski R" first="Reginald" last="Gorczynski">Reginald Gorczynski</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Surgery, University Health Network</s1><s3>CAN</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Surgery, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Butany, Jagdish" sort="Butany, Jagdish" uniqKey="Butany J" first="Jagdish" last="Butany">Jagdish Butany</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Pathology, University Health Network</s1><s3>CAN</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pathology, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Leibowitz, Julian" sort="Leibowitz, Julian" uniqKey="Leibowitz J" first="Julian" last="Leibowitz">Julian Leibowitz</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Microbial and Molecular Pathogenesis, Texas A&M University System- HSC</s1><s2>College Station, Texas</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Microbiology, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Surgery, University Health Network</s1><s3>CAN</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Surgery, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, M James" sort="Phillips, M James" uniqKey="Phillips M" first="M. James" last="Phillips">M. James Phillips</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Pathology, University Health Network</s1><s3>CAN</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pathology, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N." last="Fish">Eleanor N. Fish</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Coronavirus Infections (etiology)</term><term>Coronavirus Infections (genetics)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (pathology)</term><term>Cytokines (genetics)</term><term>Cytokines (metabolism)</term><term>DNA, Complementary (genetics)</term><term>Disease Models, Animal</term><term>Female</term><term>Hepatitis A virus</term><term>Humans</term><term>Interferons (genetics)</term><term>Interferons (metabolism)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Mice</term><term>Mice, Inbred A</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Inbred C57BL</term><term>Microbiology</term><term>Microscopy, Electron</term><term>Models</term><term>Mouse</term><term>Murine hepatitis virus</term><term>Murine hepatitis virus (classification)</term><term>Murine hepatitis virus (immunology)</term><term>Murine hepatitis virus (pathogenicity)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Severe Acute Respiratory Syndrome (etiology)</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe acute respiratory syndrome</term><term>Species Specificity</term><term>Strain</term><term>Virology</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN complémentaire (génétique)</term><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Animaux</term><term>Cytokines (génétique)</term><term>Cytokines (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (génétique)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (étiologie)</term><term>Interférons (génétique)</term><term>Interférons (métabolisme)</term><term>Microscopie électronique</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Souris</term><term>Souris de lignée A</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris de lignée C57BL</term><term>Spécificité d'espèce</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (génétique)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (étiologie)</term><term>Séquence nucléotidique</term><term>Virus de l'hépatite murine ()</term><term>Virus de l'hépatite murine (immunologie)</term><term>Virus de l'hépatite murine (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term><term>DNA, Complementary</term><term>Interferons</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Murine hepatitis virus</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN complémentaire</term><term>ARN messager</term><term>Cytokines</term><term>Infections à coronavirus</term><term>Interférons</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term><term>Virus de l'hépatite murine</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Murine hepatitis virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Interferons</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Cytokines</term><term>Interférons</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Murine hepatitis virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de l'hépatite murine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Mice</term><term>Mice, Inbred A</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Inbred C57BL</term><term>Microscopy, Electron</term><term>Species Specificity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Microscopie électronique</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris de lignée A</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris de lignée C57BL</term><term>Spécificité d'espèce</term><term>Séquence nucléotidique</term><term>Virus de l'hépatite murine</term><term>Virus hépatite murine</term><term>Virus hépatite A</term><term>Souris</term><term>Souche</term><term>Modèle</term><term>Microbiologie</term><term>Virologie</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a life-threatening infectious disease which has been difficult to study and treat because of the lack of a readily available animal model. Intranasal infection of A/J mice with the coronavirus murine hepatitis virus strain 1 (MHV-1) produced pulmonary pathological features of SARS. All MHV-1-infected A/J mice developed progressive interstitial pneumonitis, including dense macrophage infiltrates, giant cells, and hyaline membranes, resulting in death of all animals. In contrast, other mouse strains developed only mild transitory disease. Infected A/J mice had significantly higher cytokine levels, particularly macrophage chemoattractant protein 1 (MCP-1/CCL-2), gamma interferon, and tumor necrosis factor alpha. Furthermore, FGL2/fibroleukin mRNA transcripts and protein and fibrin deposits were markedly increased in the lungs of infected A/J mice. These animals developed a less robust type I interferon response to MHV-1 infection than resistant C57BL/6J mice, and treatment with recombinant beta interferon improved survival. This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Ontario</li><li>Pennsylvanie</li><li>Texas</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="De Albuquerque, Nadine" sort="De Albuquerque, Nadine" uniqKey="De Albuquerque N" first="Nadine" last="De Albuquerque">Nadine De Albuquerque</name></noRegion><name sortKey="Baig, Ehtesham" sort="Baig, Ehtesham" uniqKey="Baig E" first="Ehtesham" last="Baig">Ehtesham Baig</name><name sortKey="Butany, Jagdish" sort="Butany, Jagdish" uniqKey="Butany J" first="Jagdish" last="Butany">Jagdish Butany</name><name sortKey="De Albuquerque, Nadine" sort="De Albuquerque, Nadine" uniqKey="De Albuquerque N" first="Nadine" last="De Albuquerque">Nadine De Albuquerque</name><name sortKey="Downey, Gregory P" sort="Downey, Gregory P" uniqKey="Downey G" first="Gregory P." last="Downey">Gregory P. Downey</name><name sortKey="Downey, Gregory P" sort="Downey, Gregory P" uniqKey="Downey G" first="Gregory P." last="Downey">Gregory P. Downey</name><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N." last="Fish">Eleanor N. Fish</name><name sortKey="Gorczynski, Reginald" sort="Gorczynski, Reginald" uniqKey="Gorczynski R" first="Reginald" last="Gorczynski">Reginald Gorczynski</name><name sortKey="Gorczynski, Reginald" sort="Gorczynski, Reginald" uniqKey="Gorczynski R" first="Reginald" last="Gorczynski">Reginald Gorczynski</name><name sortKey="Habal, Marlena" sort="Habal, Marlena" uniqKey="Habal M" first="Marlena" last="Habal">Marlena Habal</name><name sortKey="Habal, Marlena" sort="Habal, Marlena" uniqKey="Habal M" first="Marlena" last="Habal">Marlena Habal</name><name sortKey="He, William" sort="He, William" uniqKey="He W" first="William" last="He">William He</name><name sortKey="He, William" sort="He, William" uniqKey="He W" first="William" last="He">William He</name><name sortKey="Jianhua Zhang" sort="Jianhua Zhang" uniqKey="Jianhua Zhang" last="Jianhua Zhang">JIANHUA ZHANG</name><name sortKey="Jianhua Zhang" sort="Jianhua Zhang" uniqKey="Jianhua Zhang" last="Jianhua Zhang">JIANHUA ZHANG</name><name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name><name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name><name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name><name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name><name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name><name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name><name sortKey="Mingfeng Liu" sort="Mingfeng Liu" uniqKey="Mingfeng Liu" last="Mingfeng Liu">MINGFENG LIU</name><name sortKey="Mingfeng Liu" sort="Mingfeng Liu" uniqKey="Mingfeng Liu" last="Mingfeng Liu">MINGFENG LIU</name><name sortKey="Phillips, M James" sort="Phillips, M James" uniqKey="Phillips M" first="M. James" last="Phillips">M. James Phillips</name><name sortKey="Phillips, M James" sort="Phillips, M James" uniqKey="Phillips M" first="M. James" last="Phillips">M. James Phillips</name><name sortKey="Rowe, Andrea" sort="Rowe, Andrea" uniqKey="Rowe A" first="Andrea" last="Rowe">Andrea Rowe</name><name sortKey="Rowe, Andrea" sort="Rowe, Andrea" uniqKey="Rowe A" first="Andrea" last="Rowe">Andrea Rowe</name><name sortKey="Shalev, Itay" sort="Shalev, Itay" uniqKey="Shalev I" first="Itay" last="Shalev">Itay Shalev</name><name sortKey="Shalev, Itay" sort="Shalev, Itay" uniqKey="Shalev I" first="Itay" last="Shalev">Itay Shalev</name><name sortKey="Xuezhong Ma" sort="Xuezhong Ma" uniqKey="Xuezhong Ma" last="Xuezhong Ma">XUEZHONG MA</name><name sortKey="Xuezhong Ma" sort="Xuezhong Ma" uniqKey="Xuezhong Ma" last="Xuezhong Ma">XUEZHONG MA</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Leibowitz, Julian" sort="Leibowitz, Julian" uniqKey="Leibowitz J" first="Julian" last="Leibowitz">Julian Leibowitz</name></region><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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